Actual trends in locally advanced cervical cancer (LACC) image-guided radiotherapy ( IGRT)

Radiotherapy (RT) is a key method for locally advanced cervical cancer (LACC) multimodal treatment, and its improvement, based on image-guided tumor dose escalation with maximum normal tissues sparing, can influence significantly the results at whole. The paper represents the image-guided radiotherapy (IGRT) main concept, terms and principals of planning applied to external beam RT and brachytherapy of LACC. It was emphasizes the capabilities and perspectives of sonography (ultrasound, US) in 2D-3D grey scale and doppler regimes as a basic method of medical visualization for GYN RT image-guided planning and monitoring. There was highlighted the importance of dose equivalence evaluation by linear-quadratic model application while choosing optimal combined RT regimes; the advantages and disadvantages of intense-modulated RT versus high dose rate brachytherapy in LACC treatment were discussed. We resumed that individual RT planning using CT-MR-US images for 3D-reconstruction with dynamic RT optimization according to dose-volume histogram evaluation during the treatment process has its own value for efficient and safe LACC multimodal treatment.