Современные возможности диагностики и лечения разрывов менисков коленного сустава
Автор: Кудрачев Т.Р., Азаркин К.М., Гончарук Ю.Р., Лычагин А.В., Тимашев П.С., Липина М.М., Петров П.И., Кавалерский Г.М.
Журнал: Кафедра травматологии и ортопедии @jkto
Рубрика: Обзор литературы
Статья в выпуске: 4 (50), 2022 года.
Бесплатный доступ
Мениски коленного сустава являются важными анатомическими структурами, повреждение и потеря которых стремительно ведет к развитию остеоартроза. На сегодняшний момент при лечении разрыва мениска приоритетной задачей является восстановление менисковой ткани. Для реконструкции необходимо воссоздать архитектуру и расположение клеток внутри мениска. Решением данной проблемы давно занимается регенеративная медицина.Цель данной работы. Обзор современной отечественной и зарубежной литературы, посвященной теме восстановления ткани мениска при помощи методов тканевой инженерии с использованием скаффолдов. В обзоре отражена актуальность проблемы лечения повреждений менисков коленного сустава, подробно обсуждаются возможности использования современных достижений регенеративной медицины, а также 3Д печати скаффалдов мениска.Материалы и методы.В ходе работы был проведен обзор отечественных и зарубежных публикаций за последние 5 лет. Поиск отечественных публикаций проводился в базе данных elibrary.ru, зарубежных - в базах данных PubMed, Scopus, MEDLINE, Cochrane library. В поиск включили оригинальные доклинические исследования invivo, связанные с тканевой инженерией менисков коленного сустава.Выводы. Использование комбинированных скаффолдов с целью замещения ткани мениска является перспективным направлением регенеративной медицины. Доступные коммерческие варианты скаффолдов показывают хорошие краткосрочные результаты лечения, возможности образования неоменисковой ткани на месте лизированных скаффолдов. Для достижения полной регенерации и восстановлению всех функции мениска исследователи продолжают активно разрабатывать и исследовать в эксперименте различные материалы и методы модификации каркасов.
Регенерация менисков, лечение менисков, тканевая инженерия, скаффолды менисков
Короткий адрес: https://sciup.org/142237450
IDR: 142237450 | DOI: 10.17238/2226-2016-2022-4-57-66
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