Modern view on radiofrequency denervation of renal arteries

Today, arterial hypertension is one of the most important health problems. It is also the main cause of cardiovascular complications and death. Despite significant success of modern antihypertensive pharmacotherapy, 10 % of the entire patient population with high blood pressure have extremely low sensitivity to core drugs aimed at BP correction. According to large clinical studies, the risk of myocardial infarction, stroke and other adverse cardiovascular outcomes in individuals with resistant hypertension is several times higher than in patients with controlled blood pressure. The purpose of this work is to analyze scientific literature on the history of development, effectiveness and safety of catheter radiofrequency denervation of renal arteries in patients with resistant arterial hypertension. The authors used articles from Pubmed, eLIBRARY, etc. for their analysis. The results of clinical studies show that patients with resistant arterial hypertension, in contrast to patients with controlled blood pressure, have more pronounced sympathetic activity. Hyperactivity of this part of the nervous system may be one of the main pathogenetic factors causing development of resistance to pharmacotherapy. Thus, radiofrequency renal denervation, modulating the tone of the sympathetic nervous system, is of particular interest.