The ability of agonist к-opioid receptor U-50,488 to simulate the phenomenon of ischemic postconditioning

The study examined the ability of к1-opioid receptors (OR) agonist, U-50.488, in doses of 0.1 and 1 mg/kg to simulate ischemic postconditioning of the heart. Duration of ischemia was 10 or 45 min and duration of reperfusion was 10 min or 2 h. Data demonstrated that the introduction of U-50.488 in a dose of 1 mg/kg both before ischemia and 5 min before reperfusion had a pronounced antiarrhythmic effect. Injection of U-50.488 5 min before reperfusion facilitated a decrease in the ratio of infarct area/area at risk by 2 times. Antiarrhythmic effect of к-OR agonists depended on the activation of к-OR.