Способы уменьшения накопления радиоактивности в почках при таргетной терапии с использованием малых молекул, пептидов и фрагментов антител

Автор: Авров К.О., Шатик С.В., Самойлович М.П.

Журнал: Сибирский онкологический журнал @siboncoj

Статья в выпуске: 4 т.23, 2024 года.

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Введение фармпрепаратов, содержащих радиоактивные изотопы и способных специфически связываться с определенными белками, является одним из подходов, применяемых при лечении или диагностике злокачественных опухолей. При этом важной задачей является решение проблемы накопления радиоактивности в почках после введения в организм радиоконъюгатов с молекулярной массой менее 70 КДа. Цель исследования - выявление наиболее эффективных подходов, способствующих уменьшению накопления радиоактивности в почках при использовании радиоконъюгатов в ходе диагностики и таргетной терапии опухолевых заболеваний. Материал и методы. Проведен поиск литературы по теме обзора в электронных базах данных PubMed, Scopus и Web of Science в период с 1987 по 2023 г., 82 статьи использовано при написании обзора.

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Радиофармпрепараты, накопление радиоактивности в почках, таргетная терапия, опухоли

Короткий адрес: https://sciup.org/140307083

IDR: 140307083 | DOI: 10.21294/1814-4861-2024-23-4-162-171

Список литературы Способы уменьшения накопления радиоактивности в почках при таргетной терапии с использованием малых молекул, пептидов и фрагментов антител

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