Indices of cortisol and dehydroepiandrosterone sulfate as potential biomarkers of efficiency of antipsychotic therapy in first psychotic episode patients

Background. The inconsistency of literature data on the effects of antipsychotics of the first and second generations on the levels of prolactin and sex hormones dictates the need for comparative studies of the levels of these hormones at various stages of antipsychotic therapy. Objective. A study of the dynamics of prolactin, estradiol and testosterone levels in serum in patients with paranoid schizophrenia during antipsychotic therapy. Materials and Methods. In 131 patients with paranoid schizophrenia under monotherapy with olanzapine, clozapine, quetiapine and haloperidol, the parameters of prolactin, estradiol and testosterone are studied by the enzyme immunoassay method. Hormonal parameters are identified at baseline (background), by weeks 3-4 and 6-8 of therapy. Results. Haloperidol therapy, regardless of the background values, leads to a significant (p