The comparative characteristic of chronic osteomyelitis causative agents depending on pyogenic process localization

The results of microbiological studying the wound diskharge from 24 patients with upper limb chronic osteomyelitis and 131 patients with lower limb chronic osteomyelitis have been analyzed. The specific composition of chronic osteomyelitis causative agents has been demonstrated to depend on the process localization. The segments involved by their degree of infection load can be arranged in ascending order: forearm-arm-leg-femur. In patients with lower limb chronic osteomyelitis the structure of microcenosis was characterized by the increase of bacterial specific variety comparing with the upper limb, and it was remarkable for a lot of isolated Gram-negative bacteria of high persistent potential, that, thereby, led to a prolonged course of pyogenic infection. Nevertheless, S. aureus, which is isolated in monoculture in 75,7% and 44,4%, respectively, is the main causative agent of pyogenic process for both the upper limb and the lower one. The persistent properties of the causative agents revealed in patients with chronic lower limb osteomyelitis are also confirmed by high frequency of the methicillin-resistant staphylococci determined in comparison with upper limb involvement.