Comparative evaluation of inflammation factors at the peripheral and coronary atherosclerosis

The inflammation is a basis of pathogenesis of an atherosclerosis and destabilization of the atherosclerotic plaque. However ways of liquidation of inflammatory process at this disease are not found. Heterogeneity of initiation of the system inflammatory answer at an atherosclerosis causes necessity of studying factors of an inflammation and its correlation with traditional metabolic disorders at an atherosclerosis of various localizations. Proteins of acute phase of an inflammation, general blood count and markers of oxidizing stress are analyzed in this article. Materials and methods of research included the analysis of the clinic and laboratory data at 30 patients with a peripheral (in iliac-femoral arterial pool) atherosclerosis (PA) and at 43 patients with coronary atherosclerosis (CA). It is established, that all patients have high level of C-reactive protein (CRP) in blood serum. It increases more, then 2 times concerning the control at all patients, but relationships of cause and effect of this increase at PА and CА were various. There are strong and positive correlation between CRP and blood glucose level, between CRP and low density lipoprotein cholesterol, CRP and triglycerides at CA patients. There was found correlation between CRP and body mass index, CRP and systolic blood pressure (SBP) at CA patients. This data suggest that the inflammation at CА is closely connected with metabolic disorders. On the contrary, at a peripheral atherosclerosis this dependence is not revealed. Correlation between CRP and total white blood cells (WBC) was (r = 62, p > 0,05), its specifies the contribution of local inflammatory reaction of peripheral tissues after chronic ischemia at PA patients. Expressed correlation between blood glucose, SBP and an inflammation, testifies to importance of metabolic syndrome in inflammation development at CA patients. Comparative estimation of inflammatory factors at peripheral and coronary atherosclerosis has shown that PA is characterized by the inflammatory reaction with high CRP level which correlates with a WBC accumulation; the oxidizing stress has the compensated character. CA is characterized by high CRP level which correlates with components of a metabolic syndrome; oxidizing stress is strong and accompanied by activation of antioxidant systems.