Comparative compressibility study of tablet GML-1 mixtures obtained by wet granulation technology
Автор: Blynskaya E. V., Yudina D. V., Alekseyev K. V., Alekseyev V. K., Minaev S. V.
Журнал: Волгоградский научно-медицинский журнал @bulletin-volgmed
Рубрика: Обзорные статьи
Статья в выпуске: 3 (63), 2019 года.
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The study investigates the effect of solvent nature on the compression characteristics of wet-granulated tableting mixtures of a new anxiolytic active pharmaceutical ingredient GML-1. Laser diffraction method was used to determine mesh-size distribution of granulated tablet mixtures. Compressibility was determined using the «out-of-die» Heckel (equation 1) and Kawakita models (equation 3).
Wet granulation, compressibility, gml-1, kawakita equation, heckel equation, mesh-size distribution
Короткий адрес: https://sciup.org/142224344
IDR: 142224344
