Comparative results of surgical and combined modality treatments for locally advanced recurrent laryngeal cancer (RT3N0M0) (part I)

The purpose of the study was to increase the treatment efficacy for patients with recurrent laryngeal cancer (rТ3N0М0) using intensive preoperative radiation therapy. A total of 190 patients were included into the study and divided into 2 groups. Group I consisted of 131 patients who underwent surgery. Group II comprised 59 patients who received preoperative radiation therapy at a total dose of 12 Gy delivered in 2 fractions (6 Gy single radiation dose on a day prior to surgery and on a day of surgery). Preoperative radiation therapy was shown to significantly increase the recurrence-free survival of patients and effect no on postoperative wound healing. The 3-year survival rate was 70.6 % for Group I patients and 83.6 % for Group II patients.