Comparative analysis of fluid therapy in coronary artery bypass grafting surgery

Our prospective, randomized, simple-blinded, pilot study investigates the influence of fluid therapy by using balanced crystalloid solution, 4% solution of gelatin polysuccinate, and 6% hydroxyethyl starch 130/0.42 on the extravascular lung water content in patients with coronary artery bypass grafting surgery. The aim of fluid therapy was to maintain a global end diastolic volume index within 680-850 ml/m 2. Transpulmonary thermodilution was used to determine an extravascular lung water index. Saturation of mixed venous blood, lactate, fluid balance, and hemodynamics were also investigated. It was shown that fluid therapy with the use of balanced crystalloid solution does not enhance the extravascular lung water content as compared with the use of colloid solutions. To achieve appropriate oxygen delivery, the effective infused volume of crystalloid solution was the double of that of colloid solutions.