Proliferation regulations, their diagnostics efficacy in patients with thyroid adenoma

The article features new research data on phenolypes flow cylomelry in thyroid gland follicular adenoma tissue of general markers CD95, CD95L, p53(р53bright, р53dim), bcl-2 (bcl-2bright, bcl-2dim), Ki-67, participating in apoplosis regulation and proliferation, as well as in expression of membranous and intracellular protein/ receptors in thyroid adenoma tissue and their diagnostic efficacy. 2 types of TGA were identified, different in phenolype. The key difference of Type II Adenoma from main group of benign tumors (Type I Adenoma) was increased number of cells with membranous receptor FAS-L. According to the research data, diagnostic frequency of Type II Adenoma was 19,35%. Type II Adenoma was marked by high amount of general markers cells, regulating apoplosis and proliferation, CD95L, p53, p53dim, p53brightl, Ki-67, bcl-2, bcl-2dim, bcl-2bright, which had different diagnostic efficacy characteristics. Thus TGAs differed in tissue cells phenolype; Type II Adenoma was more aggressive with less successful treatment perspectives.