Comparative analysis of clinical manifestations of metastasis of differentiated adenocarcinoma and undifferentiated gastric cancer

The comparative analysis of clinical manifestations of metastasis in undifferentiated gastric cancer and differentiated adenocarcinoma showed that undifferentiated cancer represents a special kind of gastric tumor significantly differed from «classic» differentiated adenocarcinoma not only by morphological structure but also by clinical manifestations of metastatic disease. Undifferentiated gastric cancer has a tendency towards increased incidence and occurs more frequently in younger patients and in women, more often affects the stomach totally, has big sizes and is characterized by predominance of infiltrative forms and early local and regional metastasis. The major way of undifferentiated gastric cancer progression is peritoneal dissemination, while in differentiated adenocarcinoma, it is hematogenous metastasis mainly in the liver. The detected characteristics should be considered in planning the extent of surgery and in choosing neo/ adjuvant chemotherapy for patients with different morphological types of gastric cancer