Comparative analysis of long-term results of surgical and combination therapy for differentiated adenocarcinoma and undifferentiated gastric cancer

He comparative analysis of long-term results of surgical and combined modality treatment for differentiated adenocarcinoma and undifferentiated gastric carcinoma (UGC) has been presented. Treatment outcomes of patients with differentiated adenocarcinoma were shown to be significantly superior to those of patients with UGC (р=0,001). Intensive preoperative radiation therapy at a total dose of 20–27 Gy resulted in a significant improvement of treatment outcomes in patients with UGC, showing no any improvement of treatment outcomes in patients with differentiated adenocarcinoma. The benefits of combination treatment for patients with UGC were observed in cases with tumors not spreading through the serosa (рТ 1–3) and with no evidence of regional lymph nodes involvement (N 0).