Comparative analysis of antitumor efficiency of photodynamic therapy with amidoaminchlorine and liposomal form of amidoaminchlorine in experimental tumor M-1

The purpose of the study was to compare antitumor efficiency of photodynamic therapy with amidoaminchlorine and its liposomal form. The research was carried out with the use of experimental model sarcoma M-1 implanted in white female rats. One group of rats received amidoaminchlorine, the second group received liposomal form of the photosensitizer, parameters of laser radiation were identical. In 3.5 hours following intraperitoneal administration of amidoaminchlorine or its liposomal form the tumor was irradiated by laser. Antitumor efficiency of the treatment was evaluated on the 21 day by the index of absolute tumor growth inhibition. For data analysis statistical software “Statistica” was used. Analysis showed that amidoaminochlorine and its liposomal form are effective photosensitizers, however, the latter was more effective.