Стабильный кастрационный уровень тестостерона при андрогенной депривации как фактор прогноза оптимального клинического контроляу больных раком предстательной железы
Автор: Грицкевич Александр Анатольевич, Мишугин Сергей Владимирович, Теплов Александр Александрович, Русаков Игорь Георгиевич
Журнал: Злокачественные опухоли @malignanttumors
Рубрика: Собственные исследования
Статья в выпуске: 1 (12), 2015 года.
Бесплатный доступ
Одной из важнейших стратегий лечения рака предстательной железы является достижение и поддержание эффективного подавления уровня тестостерона у мужчин, получающих андрогенную депривацию. Исторически уровень тестостерона ниже 50 нг/дл расценивался как кастрационный. Текущие данные показывают, что в попытке максимизировать терапевтический результат новой целью для любой хирургической или химической кастрации является уровень тестостерона ниже чем 20 нг/дл. Эффект «вспышки», обусловленный введением аналога лютеинизирующего рилизинг-гормона, может вызвать увеличение уровня тестостерона, иногда до некастрационных значений. Изучение андрогенной аблации заключается в выявлении тех агентов, при помощи которых достигаются и поддерживаются какие возможно самые низкие уровни тестостерона.
Рак предстательной железы, тестостерон, простатспецифический антиген, трипторелин
Короткий адрес: https://sciup.org/14045523
IDR: 14045523
Список литературы Стабильный кастрационный уровень тестостерона при андрогенной депривации как фактор прогноза оптимального клинического контроляу больных раком предстательной железы
- Каприн А. Д., Старинский В. В., Петрова Г. В. Злокачественные новообразования в России в 2013 году. М., 2015.-С.9-15
- Pagliarulo, V. Contemporary role of androgen deprivation therapy for prostate cancer/Pagliarulo, V. //Eur.Urol.-2012.-Vol.61.-Р. 11-25
- Shahinian VB, Kuo YF, Gilbert SM. Reimbursement policy and androgen-deprivation therapy for prostate cancer. N Engl J Med 2010; 363: 1822-1832
- Pagliarulo V, Bracarda S, Eisenberger MA, Mottet N, Schrder FH. Contemporary role of androgen deprivation therapy for prostate cancer. EurUrol 2012; 61: 11-25
- Arnold M, Karim-Kos HE, Coebergh JW, et al. Recent trends in incidence of five common cancers in 26 European countries since 1988: Analysis of the European Cancer Observatory. Eur J Cancer. 2013 Oct 8. pii: S0959-8049 (13) 00842
- De Angelis R, Sant M, Coleman MP, et al; EUROCARE-5 Working Group. Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE-5-a population-based study. LancetOncol 2014 Jan;15 (1):23-34.)
- Cancer incidence in Sweden 2004. The National Board of Health and Welfare: Stockholm
- Heidenreich A, Bellmunt J, Bolla M et al (2011) EAU Guidelines on prostate cancer. Part I: screening, diagnosis and treatment of clinically localized disease. EurUrol 59:61-71
- Mottet N, Bellmunt J, Bolla M et al (2011) EAU guidelines on prostate cancer. Part II: treatment of advanced, relapsing, and castration-resistant prostate cancer. EurUrol 59:572-583
- Studer UE, Whelan P, Albrecht W et al (2006) Immediate or deferred androgen deprivation for patients with prostate cancer not suitable for local treatment with curative intent: europeanOrganisation for Research and Treatment of Cancer (EORTC) Trial 30891. J ClinOncol 24 (12):1868-1876
- Small EJ, Ryan CJ (2006) The case for secondary hormonal therapies in the chemotherapy age. J Urol 176 (6 Pt 2):66-7
- Koutsilieris M, Dimopoulos T, Milathianakis C et al (2007) Combination of somatostatin analogues and dexamethasone (anti-survival-factor concept) with luteinizing hormone-releasing hormone in androgen ablation-refractory prostate cancer with bone metastasis. BJU Int 100 (Suppl 2):60-62
- Serrate C, Loriot Y, De La Motte Rouge T et al (2009) Diethylstilbestrol (DES) retains activity and is a reasonable option in patients previously treated with docetaxel for castration-resistant prostate cancer. Ann Oncol 20 (5):965
- Tunn UW (2011) A 6-month depot formulation of leuprolide acetate is safe and effective in daily clinical practice: a non-interventional prospective study in 1,273 patients. BMC Urol 11:15
- Rosette J de la, Davis R 3rd, Frankel D, KoldOlesen T (2011) Efficacy and safety of androgen deprivation therapy after switching from monthly leuprolide to monthly degarelix in patients with prostate cancer. Int J ClinPract 65 (5):559-566
- Crawford ED, Tombal B, Miller K et al (2011) A phase III extension trial with a 1-arm crossover from leuprolide to degarelix: comparison of gonadotropin-releasing hormone agonist and antagonist effect on prostate cancer. JUrol 186 (3):889-897
- Raddin RS, Walko CM, Whang YE (2011) Response to degarelix after resistance to luteinizing hormone-releasing hormone agonist therapy for metastatic prostate cancer. Anticancer Drugs 22 (3):299-302
- Sarosdy MF, Schellhammer PF, Soloway MS et al (1999) Endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of goserelin acetate administered every 13 weeks to patients with advanced prostate cancer. BJU Int 83 (7):801-806
- Oefelein MG, Cornum R (2000) Failure to achieve castrate levels of testosterone during luteinizing hormone releasing hormone agonist therapy: the case for monitoring serum testosterone and a treatment decision algorithm. J Urol 164 (3 Pt 1):726-729
- McLeod D, Zinner N, Tomera K et al (2001) Abarelix Study Group. A phase 3, multicenter, open-label, randomized study of abarelix versus leuprolide acetate in men with prostate cancer. Urology 58 (5):756-761
- Morote J, Orsola A, Planas J et al (2007) Redefining clinically significant castration levels in patients with prostate cancer receiving continuous androgen deprivation therapy. J Urol 178 (4 Pt 1):1290-1295
- Schulman CC, Irani J, Morote J et al (2010) Testosterone measurement in patients with prostate cancer. EurUrol 58 (1):65-74
- Heyns CF, Simonin MP, Grosgurin P et al (2003) Comparative efficacy of triptorelinpamoate and leuprolide acetate in men with advanced prostate cancer. BJU Int 92 (3):226-231
- Radu A, Pichon C, Camparo P et al (2010) Expression of follicle stimulating hormone receptor in tumor blood vessels. N Engl J Med 363:1621-1630
- Porcara AB, Migliorini F, Petrozziello A et al (2011) Investigative clinical study on prostate cancer part IV: follicle-stimulating hormone and the pituitary-testicular-prostate axis at the time of initial diagnosis and subsequent cluster selection of the patient population. UrolInt (Epub ahead of print)
- Tombal B, Berges R (2008) Optimal control of testosterone: a clinical case-based approach of modern androgen-deprivation therapy. EurUrol (Suppl 7):15-28
- Gomella LG (2009) Effective testosterone suppression for prostate cancer: is there a best castration therapy? Rev Urol 11:52-60
- Pickles T, Tyldesly S (2011) Testosterone breakthrough during LHRH agonist androgen deprivation with curative radiation: impact on PSA kinetics and subsequent biochemical outcomes. 26th Annual Congress of the European Association of Urology, Vienna, Austria
- Perachino M, Cavalli V, Bravi F (2010) Testosterone levels in patients with metastatic prostate cancer treated with luteinizing hormone-releasing hormone therapy: prognostic significance? BJU Int 105:648-65
- Taplin ME, Regan MM, Ko YJ et al (2009) Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer. Clin Cancer Res 15 (22):7099-7105
- Smith MR, Kabbinavar F, Saad F et al (2005) Natural history of rising serum prostate-specific antigen in men castrate nonmetastatic prostate cancer. J ClinOncol 23:2918-2925
Статья научная
