Stereotactic radiosurgery of metastases of colorectal cancer in the liver. Modern trends in the development of methodology

The appearance of perfect computer methods for irradiation planning, the use of a multileaf collimator for the formation of radiation beams, improved methods of patient’s accurate and stable positioning improved the possibility of precise supply of a high dose of ionizing radiation to the target. These approaches changed the role of radiotherapy in treatment of metastases in liver. Literary data indicate the possibility of achieving 95% of local control one year after stereotactic radiotherapy, 92% in two years (and 100% for tumors less than 3 cm) with the development of radiation injuries of the third and higher degrees only in 1% of cases. The Radiotherapy Department of the European Medical Center actively uses the technique of local stereotactic radiation therapy (SBRT) for the treatment of patients with metastatic liver disease. It allows to create a high dose of ionizing radiation locally in a metastatic tumor node and to cause tumor destruction without significant effect on the healthy part of the liver. This promising direction in metastatic liver cancer treatment significantly 3 increased the possibilities of combination therapy. The article provides a review of literature on the treatment of metastatic liver damage in colorectal cancer, sigmoid and rectum cancer.