Stimulation of osteogenesis in the distraction regenerate bone with bone marrow (experimental study)

The experiments in osteogenesis stimulation in the distraction regenerate bone with autologous bone marrow were made using 9 adult dogs. It was revealed that the regenerate bone lost its zonal structure after stimulation, after 7 days of fixation, in half of the experiments. The further dynamics of osteogenesis study at fixation stages demonstrated progressive replacement of the regenerate bone connective-tissue layer with bone structures. Formation and differentiation of the regenerate bone osteoosteoid trabeculae were revealed to occur through increased density of osteogenic cellular elements and osteoblasts. Thus, the complex of the studies made shows stimulating effect of autologous bone marrow, put into the regenerate bone connective-tissue layer, on osteogenesis processes.