Stimulation of passive behavior by the transplantation of immune cells pre-treated with psychoactive drug

The article presents the results of experimental studies that demonstrate the possibility of correcting the passive behavior in animals by the transplantation of immune cells, treated with psychoactive drug. It was shown that cultivating with caffeine splenocytes of AxC57Bl/6)F1 mice with passive type of behavior modifies cell's functional activity; subsequent transplantation procedures of these cells into mice with the same type of the behavior is accompanied by stimulation of the mice motor and exploratory activity in the «open field», depending on the dose of caffeine. Changes in behavior parameters are registered on the background of the modulation of cytokine synthesis in the brain of recipients. Possible mechanisms for the modulating effect of transplanted immune cells on recipient's behavior were discussed.