Stress-response to cardiosurgical intervention in newborns and infants

To optimize the follow-up, stress and inflammatory reactivity to surgical injury and extracorporeal circulation (ECC) in newborns and infants with congenital heart diseases (CHD) was studied and evaluated. 98 patients operated under ECC and normothermia were examined, their age varying from 3 days to 12 months. The criteria for inclusion were: a patient's age (up to 1 year), uneventful early follow-up. It was found out that in newborns and infants there was a low functional reserve of the adrenal cortex despite a considerable increase in its activity. Also observed were insufficient activity of antioxidant protection and strengthening of peroxide processes against the background of an acute form of the response in children of this age group.