Structural-and-biochemical parallels in the assessment of leg muscles in patients with congenital defects of leg bones

The comparative assessment by the methods of sonography and biochemical analysis of muscular structure in 30 patients with congenital defects of leg bones at the stages of treatment-and-rehabilitative process. The activity of creatine kinase (CK), lactate dehydrogenase (LDG), its isoenzymic spectrum were determined in blood serum as well as the concentration of the products of lactic acid (LA) and pyruvic acid (PA) glycolysis. The decrease of the functional activity of skeletal muscles and the absence of limb weight-bearing during ontogenetic development results in fibrous reorganization of skeletal muscles and leads to unreversible loss of contractile properties by muscles. The process of treatment with the Ilizarov fixator has no effect on the qualities of echo-density (structural changes) and on the level of muscular atrophy. The change of serum fraction proportion in favour of LDG1-2 has been revealed, that is characteristic of the early stages of skeletal muscle embryonal development, and in this case LDG and CK activity preservation within normal limits points to the absence of the signs of muscular dystrophy development. The dynamics of muscular degenerative change degree after inducing the weight-bearing of the limb is determined by its functional activity.