Study of Serum Magnesium Levels and Its Relation to Glycemic Control in Patients with Type 2 Diabetes Mellitus
Автор: Ashok V., Padmini P.J.
Журнал: Журнал стресс-физиологии и биохимии @jspb
Статья в выпуске: 4 т.16, 2020 года.
Бесплатный доступ
Background and objectives: Diabetes mellitus is the most common endocrine disorder and the leading cause of death and disability in the world. Magnesium is the most common intracellular cation involved in insulin mediated glucose uptake. This study was conducted in type 2 diabetic patients to assess fasting blood glucose (FBS), HbA1c and serum magnesium levels and compare it with normal controls. Materials and Methods: This was a case control study which included 50 patients with type 2 diabetes mellitus and 50 healthy controls. Serum magnesium was estimated by calmagite endpoint method. HbA1c was estimated by immunoturbidimetry method. Statistical analysis was done using SPSS. Results and discussion: Decrease in mean level of serum magnesium were observed among diabetic patients. A negative correlation was observed between serum magnesium and HbA1c. A linear regression analysis showed an inverse relationship between serum magnesium and glycemic control among patients with diabetes mellitus. Conclusion: We concluded that type 2 diabetic patients who are at risk of developing microvascular complications with poor glycemic control must be regularly monitored for serum magnesium levels.
HbA1C, diabetes mellitus, magnesium, glycemic control
Короткий адрес: https://sciup.org/143173866
IDR: 143173866
Список литературы Study of Serum Magnesium Levels and Its Relation to Glycemic Control in Patients with Type 2 Diabetes Mellitus
- Champe P.C., Harvey R.A., Ferrier D.R. (2005) Illustrated Biochemitry, Diabetes Mellitus. 3rd ed. USA: Lippincott, Williams and Wilkins, P 342-351.
- Dasgupta, A., Sarma, D., & Saikia, U.K. (2012). Hypomagnesemia in type 2 diabetes mellitus. Indian journal of endocrinology and metabolism, 16(6), 1000.
- Fowler, M.J. (2008). Microvascular and macrovascular complications of diabetes. Clinical diabetes, 26(2), 77-82.
- Geiger, H., & Wanner, C. (2012). Magnesium in disease. Clin Kidney J. 5 (Suppl 1), i25–i38.
- Glindler, E.M., Hetti, D.A. (1971). Colorimetric determination with bound “Calmagite” of magnesium in human blood serum. Clin Chem, 17, 662.
- Jeppsson, J.O., Kobold, U., Barr, J., Finke, A., Hoelzel, W., Hoshino, T., Miedema, K., Mosca, A., Mauri, P., Paroni, R., Thienpont, L., Umemoto, M. & Weykamp C. (2002). Approved IFCC reference method for the measurement of HbA1c in human blood. Clinical Chemistry and Laboratory Medicine (CCLM), 40(1), 78-89.
- Kundu, D., Osta, M., Mandal, T., Bandyopadhyay, U., Ray, D., & Gautam, D. (2013). Serum magnesium levels in patients with diabetic retinopathy. Journal of natural science, biology, and medicine, 4(1), 113.
- Rao, Y.S., & Rao, V.D. (2016). Serum magnesium levels in type 2 diabetes. Int J Res Med Sci, 4, 991-994.
- Sacks, D.B., Bruns, D.E., Goldstein, D.E., Maclaren, N.K., McDonald, J.M., & Parrott, M. (2002). Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clinical chemistry, 48(3), 436-472.
- Saeed, H., Haj, S., & Qasim, B. (2019). Estimation of magnesium level in type 2 diabetes mellitus and its correlation with HbA1c level. Endocrinology, Diabetes & Metabolism, 2(1), e00048.
- Sales, C.H., & Pedrosa, L.D.F.C. (2006). Magnesium and diabetes mellitus: their relation. Clinical nutrition, 25(4), 554-562.
- Saris, N.E.L., Mervaala, E., Karppanen, H., Khawaja, J. A., & Lewenstam, A. (2000). Magnesium: an update on physiological, clinical and analytical aspects. Clinica chimica acta, 294(1-2), 1-26.
- Sicree, R. (2006). Diabetes and impaired glucose tolerance. Diabetes atlas, 15-109.
- Supriya, M.S., Pinnelli, V.B., Murgod, R., & Raghavendra, D.S. (2013). Evaluation of serum copper, magnesium and glycated haemoglobin in type 2 diabetes mellitus. Asian J Pharm clin res, 6(2), 188-90.
- Trinder, P. (1969). Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Annals of clinical Biochemistry, 6(1), 24-27.
