Study on the Hippocampal Neuron's Minimal Models' Discharge Patterns

Study on the Hippocampal Neuron's Minimal Models' Discharge Patterns

Автор: Yueping Peng, Haiying Wu, Nan Zou

Журнал: International Journal of Image, Graphics and Signal Processing(IJIGSP) @ijigsp

Статья в выпуске: 4 vol.3, 2011 года.

Бесплатный доступ

The hippocampal CA1 pyramid neuron has plenty of discharge actions. The one-compartment model of CA1 pyramid neuron developed by David is a nine-dimension complex dynamic model. In the thesis, the currents related to the nine-dimension complex model are analyzed and classified by the model’s reduction theory and methods based on neurodynamics, and four minimal models are gotten: (INa+IKdr)-minimal model, (INa+IM)-minimal model, (INa+ICa+Iy)-minimal model, and (INa+ICa+IsAHP)-minimal model. These minimal models have plenty of dynamic actions, and under the current’s stimulation, they can all generate regular discharge and have period discharge pattern, bursting pattern, the chaos discharge pattern, and so on. Compared with the initial nine-dimension complex model, these minimal models’ dimension are much reduced, and are more convenient to numerical simulation, calculating, and analyzing. In addition, these minimal models provide a simpler and flexible method to discuss the specific currents’ dynamic characteristics and functions of the initial nine-dimension complex model by the theory of neurodynamics.

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Neuron, the minimal model, discharge pattern

Короткий адрес: https://sciup.org/15012157

IDR: 15012157

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