Studying of the system IL-1 and G-CSF in hydronephrosis as a perspective of creating new diagnostic test systems
Автор: Vechkanova Natalia, Stepanov Nikita, Mashnin Igor, Duvayarov Z., Selkin V.
Журнал: Бюллетень науки и практики @bulletennauki
Рубрика: Медицинские науки
Статья в выпуске: 3 т.5, 2019 года.
Бесплатный доступ
Hydronephrosis refers to diseases of the urinary system, which are characterized by high prevalence. Moreover, this pathology of all obstructive uropathies, leading to a decrease in the function of the renal parenchyma, accounts for up to 15% of cases. Therefore, the search for various markers involved in the development and progression of kidney damage is particularly relevant, since in the literature there are very contradictory data. Our article presents the results of a survey of 40 patients with established and confirmed diagnosis of stage I hydronephrosis (according to the classification of N. A. Lopatkin), and 20 completely healthy people (control group). All patients initially and at the end of the study determined the levels of cytokines: IL-1a, IL-1b, IL-1ra and G-CSF. We found that patients with hydronephrosis had higher rates of pro-inflammatory components of the IL-1β system: IL-1β - 104.42 (75% CI [111.8-151.4]) pg/ml, which was significantly higher than in the control group 3.7 times...
Hydronephrosis, obstructive uropathy, il-1, g-csf
Короткий адрес: https://sciup.org/14115326
IDR: 14115326 | DOI: 10.33619/2414-2948/40/07
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