Suicides and synthetic cationins. Clinical-genetic analysis

Suicide is a serious public health issue and it accounts for almost 2% of deaths worldwide (WHO). In the etiology of suicides, the genetic component is important. The study present research of polymorphisms in the DRD2 Taq1, DRD4 (V120), DAT1 (V40), T102CHTR2A (rs6313), HTR1B genes in patients who have the addiction on synthetic cathinones (n=182) volunteers residing in the Republic of Bashkortostan, including a subgroup of individuals (n=74) those who had one attempt at suicide. The control group included 157 persons with different ethnic characteristics, gender, age. People who had a mental disorder were excluded. The aim of the study is to investigate the effect of these polymorphisms on addiction to synthetic cathinones and the development of suicidal behavior. The results of the study revealed that the addicts with a suicidal attempt had a more frequent detection of the geno-type*A1/*A1 DRD2 (χ2=5,893; Р=0,05), genotype *10/*10 gene of the transport of dopamine DAT1 (V40) (χ2=11,055; p=0.025) and the genotype *C/*C of the T102C polymorphism of the 2A-5-HTR2 gene (χ2=9,146; р=0,01). This article might be of interest to professionals engaged in narcology, psychiatry, and suicidology.