Beta-adrenoreceptors genetic polymorphism connection with beta-bloker therapy efficacy in patients with cardiovascular disorders

At present it is obvious that genetic peculiarities of patients are the major reason for individual differences in pharmacological responses to р-adrenoblockers. Furthermore ADRB1 gene polymorphism is responsible for the efficiency of р-adrenoblockers. Thus, a real prospect exists for an individualized approach to administration of р-adrenoblockers and selection of dosage based on patient's genotype, which must undoubtedly increase efficiency of the administered therapy. Reviewfocuses on gene polymorphism responsible for р-adrenoblockers pharmacodynamics and on the clinical significance of the polymorphism detection to individualize drug therapy based on patient's genotype.