Association of COL1A1 gene Sp1 polymorphism with bone mineral density in postmenopausal women

There are contradictory data on influence of COL1A1 gene Sp1 polymorphism on the bone tissue mineral density and risk of osteoporosis developing. The objective of the paper is to study associations between Sp1 polymorphism of COL1A1 gene and mineral density of various skeletal sites in postmenopausal women. Materials and Methods. 483 postmenopausal women were examined in the trial. Dual-energy X-ray absorptiometry was used to obtain densitometry indexes. Real-time PCR was used for determination of polymorphism of 1546 (6252) G>T [Sp1 S>s] of COL1A1 gene. Results. It was found out that postmenopausal women with GG genotype Sp1 polymorphism of COL1A1 gene had higher rates of body weight, than other patients (р=0.044), and their body mass index is also higher in comparison with GT genotype (p=0.047). GT genotype in comparison with GG genotype was associated (р=0.005) with decrease in bone mineral density and T-criterion in L1-L4 lumbar spine, left and right proximal femurs, including left and right femoral neck. Also TT genotype was associated with decrease in the above-stated densitometry indexes at the left proximal femur (р=0.004). Conclusion. The obtained data can be used to develop criteria for predisposition to osteoporosis in postmenopausal women, early disease diagnosis and increase of medical-preventive activities.