Management of premature ejaculation in patients with erectile disfunction

Introduction. Early ejaculation mixed with ED is quite an often combination, mentioned in clinical guidelines. Management of these two conditions results in prescribing both SSRIs and PDE5i. But there is a lack of information about efficacy and safety of such combination. Aims. The study objective is to evaluate effectiveness and safety of dapoxetine (NAO «Severnaya zvezda») 30/60 mg on demand combined with tadalafil (NAO «Severnaya zvezda») 5 mg OD for managing early ejaculation and erectile disfunction. Materials and methods. Efficacy was evaluated by questionnaries (PEDT) and Intravaginal ejaculation latency time (IELT). Results. 112 were enrolled in the study, all of them have finished the study. Patients with dapoxetine dose titration - 9,2 %. Dapoxetine (NAO «Severnaya zvezda») 30/60 mg on demand combined with tadalafil (NAO «Severnaya zvezda») 5 mg OD made it possible to extand IELT for more than 300 sec. Conclusion. Dapoxetine (NAO «Severnaya zvezda») 30/60 mg on demand combined with tadalafil (NAO «Severnaya zvezda») 5 mg OD is effective and safe for managing early ejaculation and erectile disfunction. This therapy prolongs intravaginal ejaculation delay by more than 300 seconds.