The olfactory system regulates acute mountain sickness

The olfactory system regulates acute mountain sickness

Автор: Venkatesh Thuppil, Casikar Vidyasagar, Nagabhushan Savitha

Журнал: Журнал стресс-физиологии и биохимии @jspb

Статья в выпуске: 1-2 т.5, 2009 года.

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OBJECTIVE: Hyperventilation is the first response to hypoxia in high altitude (HA). Our study on rats was designed to establish an integrated hypothesis to include hyperventilation, increased activity of hypothalamic- pituitary-adrenocortical axis (HPA) in response to initial exposure to hypoxia and failure of adaptation to stress in olfactory bulbectomised rats.. METHODS: Albino rats whose olfactory lobes were removed were subjected to hypoxia and hypothermic conditions. Blood and urine samples were collected at various stages to measure biochemical parameters. Rats whose olfactory systems were intact were used as controls. RESULTS: The results suggested that the olfactory system regulated pituitary function and that in rats whose olfactory lobes were removed failed to adapt to the stress created by hypoxia and hypothermia. CONCLUSIONS: Acute Mountain Sickness (AMS) is a type of stress. Normal rats when subjected to stress such as AMS are able to adapt. This adaptation is lost when the olfactory bulbs are removed. It is postulated that serotonin receptors in the hypothalamus, through the splanchnic pathway regulate stress. This mechanism is independent of ACTH - Cortisol feed back system. Perhaps irregular and rapid respiratory rhythm simulates physiological Olfactory Bulbectomy during rapid climbing and AMS manifests as a failure of stress adaptation.

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Hyperventilation, olfactory bulb, hypothalamus, endocrine dysfunction, ams, adaptation, stress regulation

Короткий адрес: https://sciup.org/14323472

IDR: 14323472

Список литературы The olfactory system regulates acute mountain sickness

  • Acosta J. de. (1941) Advances in Enzymology Volume 1. The chemical nature of catalase, Inter science Publishers 163-176.
  • Anand, I.S., et al. (1933) Body fluid compartments, renal blood flow and hormones at 6,000m in normal subjects. J Appl Physiol., 74, 1234-9.
  • Anguiano, B., and et al. (1999) Neuroendocrine regulation of adrenal gland and hypothalamus 5'deiodinase activity.II. Effects of splanchnicotomy and hypophysectomy. Endocrinology., 136, 3346-3352.
  • Basnyant, B. and Murdoch, D.R. (2003) High Altitude Illness. The Lancet, 361, 1964-74.
  • Bethea, C.L., Francis, K.Y., Fox, B.S. and et al. (2005) Sensitivity to stress-induced reproductive dysfunction linked to activity of the serotonin system. Fertility and Sterility., 83, 1, 148-155.
  • Bounviso, N., Amat, C. and Litaudon, P. (2006) Respiratory modulation of olfactory neurons in the rodent brain. Chemical Senses., 31, 2, 145-154.
  • Brown, D.E. (2002) Acute mountain sickness and physiological stress during intermittent exposure to high altitude. Ann Hum Biol., 16, 1:15-23.
  • Cairncross, K.D. (1971) Olfactory Bulbectomy as a model for depression in rats. Physiol Behav., 6, 3, 497-501.
  • Casikar, V. and Venkatesh, T. (2001) Usefulness of Regulated Breathing Under Hypoxic Conditions. High Altitude Medicine and Biology., 2, 1, abstract no 192: 270.
  • Casikar, V. (1984) Effects of Carotid Blood Flow at High Altitude, First International Congress on high altitude medicine, held at Chamonix, Paris.
  • Cassano Jr.,W. and D'mello, A.P. (2001) Acute stress-induced facilitation of the hypothalamic-pituitary-adrenal axis: evidence for the roles of stressor duration and serotonin. Neuroendocrinology 174, 3, 167-177.
  • Childers, J.W. and Schneider, E.G. (1982) Aldosterone and the enhanced natriuresis of hypertonic infusions in the dog., Renal Physiology., 242, 1, 30-37.
  • Claydon, V.E., Norcliffe, L.J., Moore., Rivera-Ch, J.P., Leon-Velarde, M., Appenzellar. and Hainsworth, R. (2004) Orthostatic tolerance and blood volumes in Andean high altitude dwellers. Physiology., 565-571.
  • De Souza, E.B. and Van Loon, G.R. (1986) Brain serotonin and catecholamine responses to repeated stress in rats. Brain Res., 367 (1-2),77-86.
  • Goddard, P.J., Keav, G. and Grigor, P.N. (1997).Lactate dehydrogenase quantification and isoenzyme distribution in physiological response to stress in red deer (Cervus elaphus). Research in Veterinary Science., 63, 119-22.
  • Grosney, J. et al. (1965) High altitude pulmonary oedema. Lancet, 30, 1, (7379), 229-234.
  • Grzybowski, J., Bilinska, Z.T., Janas, J., Michalak, E., Skwarek, M. and Ruzyllo, W. (2002) Level of angiotensin II and aldosterone in plasma is often elevated inpatients with heart failure treated with converting enzyme inhibitors-preliminary results. Przegl Lek, 2002, 59 (8), 587-589
  • Jaeschke, H. (1990) Glutathione disulfide as index of oxidant stress in rat liver during hypoxia. Am J Physiol Gastrintest Liver Physiol., 258, 499-505.
  • Kawahara, H., Yoshida, M., Yokoo, H., Nishi, M. and Tanaka, M. (1993) Psychological stress increases serotonin release in the rat amygdala and prefrontal cortex assessed by in vivo microdialysis. Neuroscience Letters., 162, 81-84.
  • Kearney, E.B., Mayr, M. and Singer, T.P. (1972) Biochemistry Biophysics Res. Comm., 46, 531-38.
  • Koga, Y. and et al.(2006) Brain creatinine functions to attenuate acute stress responses through GABAnergic system in chicks. Neuroscience., 32, (1), 65-71.
  • Konstandi, M., Johnson, E., Lang, M.A., Malamas, M. and Marselos, M. (2000) Noradrenaline, dopamine, serotonin: different effects of psychological stress on brain biogenic amines in mice and rats. Pharmacol Res., 41 (3), 341-6.
  • Majumdar, M., Tsukada, K. and Lieberman, I.(1967) Liver protein synthesis after partial hepatectomy and acute stress. The J Biological Chemistry., 4, 700-7004.
  • Marcilhac, A., Faudon, M., Anglade, G., Hery, F. and Siaud, P. (1999) An investigation of serotonergic Involvement in the regulation of ACTH and corticosterone in the olfactory bulbectomised rat. Pharmacol Biochem and Behavior.,.63 (4), 599-605.
  • Nieuwenhys, R. (1998) The Human Central Nervous System, Atlas: Springer-Verlag. 3rd edn, Berlin.
  • Roach, R.C. and Hackett, P.H.(2001) Frontiers of Hypoxia Research: Acute Mountain sickness. J Exp Biol., 204, 161-70.
  • Robinson, A., Kern, C., Foster, J.D., Fong, K.J. and Pitovski, D.Z. (1998) Expression of Gluocorticoid Receptor mRNA and Protein in the Olfactory Mucosa: Physiologic and Pathophysiologic Implications: The Laryngoscope., 108, 1238 -1242.
  • Schulte, P.M., Glemet, H.C., Fiegig, A.A. and Powers, D.A. (2000) Adaptive variation in lactate dehydrogenase-Bgene expression: Rol responsive regulatory element. 2000; Proc natl Acad Sci U.S.A., 97 (12), 6597-6602.
  • Shertzer, H.G. and Cascarano, J. (1972) Mitochondrial alterations in heart, liver and kidney of altitude acclimated rats. Am j Physiol., 223 (3), 632-636.
  • Van Hunsel, F. (1998) The influence of psychological stress on total protein and patterns obtained in serum protein. Psychological Medicine., 28, 301-309.
  • Vogel, W.H. and Jensh, R. (1998) Chronic stress and plasma catecholamine and corticosterone levels in male rats. Neuroscience Letters., 22, 87 (1-2), 183-188.
  • Walters, D.C. (1986) Stress as a principal cause of calcium oxalate urolithiasis.International Urology and Nephrology., 18, 3, 271-275.
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