Thionins of wheat Triticum kiharae Dorof. et Migush. are novel potent inhibitors of Candida albicans (C.P. Robin) Berkhout 1923

Plants serve as a source of biologically active compounds, the most important of which are antimicrobial peptides (AMPs). AMPs represent an integral part of the defense arsenal of all living beings. Members of the thionin family found only in plants, are effective inhibitors of plant pathogens, including bacteria and fungi, which opens up prospects for their practical application as biopesticides to protect plants from diseases. However, the effect of thionins on animal and human pathogens has not been sufficiently studied. Yeast-like fungi of the genus Candida are opportunistic pathogenic microorganisms that occur in 70 % of people without causing disease (M. Dadar et al., 2018). However, in immune-compromised individuals, they can cause a number of serious diseases, the frequency of which has increased significantly in the last two decades. Antimycotics traditionally used to treat Candida infections are not always effective and safe for humans. In this regard, the world is constantly searching for new natural antifungal agents...