Mast cells in combination with depletion of testicular microbiome as a factor in the pathogenesis of non-obstructive male infertility

Introduction. Male infertility is a complex disease with many potential causes, including hormonal imbalance, anatomical problems, genetic factors, lifestyle factors, and more. Currently, there is a fairly large group of infertile men with unspecified causes of the disease. Clinical case. This clinical observation demonstrates a patient whose azoospermia was caused by an increase in the number of mast cells (MC) in the interstitial tissue of the testicle and depletion of the testicular microbiome. MC in the testicle, which are in close contact with the structures of the wall of the seminiferous tubule, contribute to dysfunction of the hematotesticular barrier.