At the origins of the formation of the method of artificial blood circulation in the USSR. In memory of prominent scientists and innovators S.S. Bryukhonenko (1890-1960) and N.N. Terebinsky (1880-1959)

The main dates of the life and work of outstanding Soviet scientists S.S. Bryukhonenko and N.N. Terebinsky are presented. Their scientific cooperation is described. It is noted that the Autojector device, created by S.S. Bryukhonenko (1924), served as a prototype for all subsequent artificial blood circulation devices, both domestic and foreign, designed for interventions on the "open” heart. It is shown that an improved «Autojector» was used in intracardiac operations (performed by S.I. Chechulin), which were performed by Professor N.N. Terebinsky since 1929 (in the first operations together with S.S. Bryukhonenko) in the laboratory of the Research Chemical and Pharmaceutical Institute (NIHFI) led by Sergey Sergeevich (1926-1935). Artificial blood circulation during surgical operations on the heart, which allows to eliminate complex defects in the «open» heart under the control of vision, initiated by the experiments of S.S. Bryukhonenko and N.N. Terebinsky (1929), expanded the possibilities of cardiovascular surgery. Experiments with the «isolated head» of a dog conducted by S.S. Bryukhonenko and S.I. Chechulin were of great applied importance for cardiac surgery and transplantology. It is noted that the unique laboratory research on IC and the creation of the first device for the implementation of artificial blood circulation of the whole organism not only perpetuated the name of the talented and brilliant inventor Sergei Sergeevich, but also were important priorities of the USSR in world medical science. It is shown that domestic scientists S.S. Bryukhonenko and N.N. Terebinsky scientifically proved the possibility of: 1-artificial perfusion of the whole dog’s body, in particular the brain, oxygenated blood; 2-performing intracardiac operations under the control of vision with the use of artificial blood circulation. It is noted that N.N. Terebinsky’s experiments laid the foundation for further study of clinical cardiac surgery under the control of vision with the use of artificial blood circulation.