Postmenopausal estrogen and progesterone expression level in endometrium of females under tamoxifen

The aim of the work is to improve the diagnosis of endometrial diseases while treating breast cancer with tamoxifen in postmenopausal women. Materials and Methods. We examined 140 postmenopausal women with structural changes in the endometrium; 70 patients were taking tamoxifen (group I) and 70 were not taking tamoxifen (group II). Subsequently, all the patients were divided into groups depending on the morphological characteristics of the endometrium. A research program has been developed that provides for clinical and statistical analysis, sonographic examination of pelvic organs, uterus hysteroscopy, endometrium morphological examination, examination of ER and PR expression level, the ratio of their isoforms in the endometrium, and statistical processing of the results obtained. Results. Glandular endometrial hyperplasia in women with mammary tumors taking tamoxifen in postmenopause is characterized by high expression of receptors for steroid hormones in both glands and endometrial stroma (281...