Kiss-peptin level in women with pregnancy termination at an early stage

Currentness and purpose: kisspeptin - hormone encoded by the gene kiSS-1 is normally produced in the human brain tissue and regulates the reproductive function [1]. So far, the issues related to the change in the kisspeptin level and its participation in the processes of natural maintenance and development of pregnancy remain practically unexplored. Material and methods. To determine the kisspeptin level in women during pregnancy, three groups of women were studied: somatically and gynecologically healthy women with normal pregnancy (Group III), women with threatened miscarriage (Group I) and women with miscarriage (Group II), the kisspeptin level was determined by the method of immune-enzyme analysis with the set of Kisspeptin-54 reagents (metastin) (with extraction) (BCM DIAGNOSTICS). Results. All women, both with a threatened miscarriage and with miscarriage already occurred, showed a significant reduction of all gonadal hormones in the blood serum compared to women of the same gestational age without the threat of miscarriage. Kisspeptin level fell dozens of times in the women of the first and second groups as compared to the levels recorded in healthy pregnant women (Group III). Conclusion. Thus, kisspeptin takes part in the processes of maintenance and carrying of a pregnancy and can be used to predict the threat of miscarriage in pregnant women.