Accelerating regeneration of eye socket bone defect by modifying xenogenic elastin biomaterial

Purpose: to identify the morphological aspects of the replacement of transplanted preserved and modified xenogenic elastin biomaterials in the rat eye socket defect. Material and Methods. Wistar rats were given a 7x4 mm defect in the upper wall of the eye socket. Wistar rats were treated with a 7x4 mm defect in the upper edge of the orbit. In the first experimental group (n=30), a preserved xenogenic elastin biomaterial (pXEBM) was placed in the defect zone, and in the second experimental group (n=30), a modified porous xenogenic elastin biomaterial (mXEBM) was placed. In the control group (n=30), soft tissues were sutured in layers. The tissues were excised after 1, 3, 6 and 12 months. Histological methods were used. Results. Grafts have osteoinductive, osteoconductive properties and are replaced by a full-fledged bone regenerate. After implantation, the mXEBM was replaced 2 times faster than the pXEBM. In the control group, after 1 year, the bone defect did not spontaneously recover. Conclusion. Xenogenic biomaterials based on elastin are ultimate biomimetics. The porosity of the graft significantly accelerates the course of bone repair processes