Stimulation of collagen synthesis in mesenchymal stem cells by a low-intensity laser with a wavelength of 633 nm

Russian Academy of Sciences, Saint Petersburg 2State Budgetary Healthcare Institution ‘City Polyclinic No. 107,’ Saint Petersburg 3Clinic of Laser Surgery, Saint Petersburg 4Autonomous Non-commercial Organization for Professional Education ‘North-West Academy of Osteopathy’, Saint Petersburg 5Private Institution of Higher Education ‘Medical University ‘Reaviz,’ Samara In this experiment, we used laser radiation with a wavelength of 633 nm and a power of 1.6-1.8 mW to upregulate col2a1 genes in vitro in mesenchymal stem cells in the bone marrow of mature rats. Our findings indicate that this method can be used in clinical practice to facilitate regeneration of the damaged layer of hyaline cartilage in patients with various diseases.