Vascular-parenchymatous relations in the right atrium when using various methods of hypothermia during open-heart operations in clinical and experimental settings

A correlation analysis of interrelations between the ultrastructural changes in microvessels and a range of cardiomyocyte organelles was carried out by using biopsy samples of the right atrium. These interrelations were studied during a long-term cardiac arrest experimentally and in cardiosurgical patients differing by age, disease nosology and intraoperative anesthesia care. It was found out that the impact of microvessels carrying capacity properties upon the ultrastructure of cardiomyocyte organelles depended on the method of intraoperative anesthetic protection of the organism and on the stage of operation. Perfusionless hypothermia provided a considerably higher total quantity of correlation relationships reflecting the interrelations between the morphological changes in the coronary microvessels and cardiomyocyte ultrastructure as compared to extracorporeal circulation. At each stage of operation there was a prevailing mechanism, which cut the capillaries off the blood flow and strongly affected the ultrastructural properties of cardiomyocyte organelles.