Influence of affective disorders with different risk of suicidal behavior on survival of patients receiving conservative therapy of chronic coronary artery disease

Objective: to analyze influence of affective disorders (AD) with and without suicidal thoughts on survival rates and to study features of suicidal behavior in patients under conservative therapy of chronic coronary artery disease (CAD) who lived in Tomsk and in the Tomsk Region. Materials and Methods: A prospective cohort study (2008-2014) enrolled patients with chronic CAD (n=333) without invasive interventions; of them 230 male (mean age 59.5±9.3) and 103 female (mean age 67.9±8.9) patients. For the purpose of assessment of suicidal risk an anamnesis and clinical data regarding risk factors of suicidal behavior were analyzed as well as the corresponding item of Beck Depression Inventory (BDI). Patients received standard examination and underwent routine screening with use of BDI and ShARS. When obtaining the informed consent, patients were examined by a psychiatrist and, if there were any indications, were treated with antidepressants (n=20). Further patients were divided into 2 groups: with and without comor-bid AD. For every sample, we calculated mean and standard deviation during normal sign distribution or the median, 25% and 75% quartiles if those were absent; the statistical significance of differences between groups was determined according to Mann-Whitney (for two independent samples), Wilcoxon (for two dependent samples) criteria. For revealing interrelationship of signs, Spearman correlation analysis was used. For assessment of frequencies Fisher χ2-criterion was used. Kaplan-Meier estimate was used for measuring survival rate. Comparison of survival curves was conducted with use of log-rank test (Mantel-Cox test). Statistical processing of data was carried out with program kit Statistica-8.0. Results: In groups with and without AD, frequency of suicidal behavior (according to BDI) was significantly different statistically (18.75% and 7.9%; p=0.0054). There was disclosed the relationship of the death cases with a high total score of suicidal behavior according to BDI (rs=0.3, p