The effect of alpha-lipoic acid on urinary incontinence in women with type 2 diabetes mellitus

Diabetic autonomic neuropathy and estrogen deficiency in peri- and postmenopausal women are the leading causes of combined urinary incontinence (stressful and urgent) in women with type 2 diabetes. The study included 25 peri- and postmenopausal women aged 45-55 years (mean age 49.8±0.57 years) with type 2 diabetes mellitus and urinary incontinence. Patients were prescribed alpha-lipoic acid for 11 weeks at a dose of 600 mg in the morning on an empty stomach, 30 minutes before breakfast. Estradiol (2 mg) + dydrogesterone (10 mg) was then added to alpha-lipoic acid once daily for 11 weeks. The patients were treated with vildagliptin 50 mg/metformin 500 mg twice daily. The level of glycated hemoglobin was less than 8.5%. Treatment with alpha-lipoic acid at a dose of 600 mg after 11 weeks led to a significant decrease in the volume of residual urine according to ultrasound examination by an average of 100 ml (p0. 05). The addition of estradiol (2 mg) + dydrogesterone (10 mg) to alpha-lipoic acid for an additional 11 weeks significantly reduced residual urine volume by an average of 173 ml (p function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }