Effect of anti-antibodies to estradiol and progesterone on the concentration of hormones in the blood serum of healthy women and breast cancer patients

The relationship between autoantibodies specific to estradiol (Es)/ progesterone (Pg) and the concentrations of these hormones in the blood serum of healthy women and breast cancer patients has been previously revealed. Purpose: to study the association between anti-idiotypic antibodies to Es and Pg and the concentrations of these hormones in postmenopausal healthy women and breast cancer patients. Material and Methods. The levels of Es and Pg in the blood serum of 206 healthy women and 480 breast cancer patients were studied using competitive enzyme immunoassay. The levels of autoantibodies to Es and Pg and appropriate anti-idiotypic antibodies in the same serums were studied using non-competitive enzyme immunoassay. Results. The high personal ratio of hormones (Pg/Es >4.0) was associated with the low breast cancer risk (OR=0.3; р1.0; р=0.004) and high individual ratio of anti-idiotypic antibodies (IgG-Pg2/IgG-Es2>1.0; p