Influence of antibodies to low-molecular xeno- and endobiotics on estradiol and progesterone maintenance in blood serum of pregnant women

Specific immune reactions to low-molecular teratogens of environment and steroid hormones at the physiological course of pregnancy are studied. The maintenance of steroid hormones in blood serum met standards of the II trimester of pregnancy. Unequal nature of distribution of high and low concentration of estradiol and progesterone depending on the level of antibodies to them was revealed. At increase the levels of antibodies concentration of estradiol increases and concentration of progesterone in serum decreases. It is revealed that influence of antibodies to benzo(a)pyrene on the maintenance of steroid hormones is mediated by interrelation of immune reactions to low-molecular xeno-and endobiotics of similar chemical structure.