Effect of kispeptin receptor blockade on behavioral indicators of rats in standard tests

Kisspeptin, the regulatory peptide, is known as a fertility stimulator and reproductive regulator. Its activity is mediated by specific interaction with GPR54 receptors (or Kiss1R). There are indications of correlation between the kisspeptin system in the brain and the function of circadian oscillator, the suprachiasmatic hypothalamus nucleus, which stimulates the cells of the kisspeptin neural network of the anteroventral periventricular nucleus in the hypothalamus, which in turn leads to the release of the hypothalamic gonadoliberin in the time period immediately preceding the start of the total daily locomotor activity. There is also evidence on the presence of fibers containing kisspeptin and on kisspeptin receptor expression in the suprachiasmatic nucleus, which indicates the function of kisspeptin as a feedback signal from the reproductive to the circadian system. Along with kisspeptin reproductive function, there is evidence on its importance in the behavior regulation...