The Influence of liraglutide dose on the effectiveness of microcirculatory disorders correction in white rats with absolute insulin deficiency

The aim is to study of the dose-dependent effects of glucagon-like peptide-1 receptors agonist liraglutide on the microcirculation of white rats under the alloxan-induced insulin deficiency. Material and methods. The studies were carried out on 70 white rats, divided into 4 groups: 20 control intact animals, 20 animals of the comparison group with alloxan diabetes, 10 animals with insulin deficiency, which were injected with liraglutide at a dose of 0.2 mg / kg / day (experimental group No 1) and, 20 animals with insulin deficiency of which were treated with liraglutide at a dose of 0.4 mg / kg / day (experimental group No 2). Diabetic status, skin perfusion of the posterior paw and mechanisms of blood flow modulation were assessed in all groups of animals. Results. It was found that the administration of liraglutide at a dosage of 0.4 mg / kg / day allows achieving complete normalization of carbohydrate metabolism in rats with alloxan-induced insulin deficiency, and it is more effectively improves the state of microcirculation compared with the use of a dosage of 0.2 mg / kg / day. Conclusion. The effectiveness of the correction of microcirculatory disorders with liraglutide correlates to the correction of carbohydrate metabolism in rats with insulin deficiency and depends on the dose of the drug. The dose-dependent effect is determined by the endothelial mechanism of microcirculation modulation. At the same time, the restoration of the neurogenic component of the vascular tone is independent from the dose of liraglutide.