The influence of risk factors on immediate results of endovascular revascularization in combination with catheter-directed selectie thrombolysis in acute trombosis of peripheral arteries in patients with acute COVID-19 infection

Introduction. Acute limb ischemia is an urgent condition in which immediate revascularization is necessary. The risk of complications depends on the age of the patient, the cause of arterial thrombosis of the limb, and the presence of concomitant pathology: Coronary heart disease, CKD, respiratory failure, diabetes mellitus, urgency and duration of surgical treatment.The aim of the study was to assess the impact of the presented risk factors on the results of endovascular revascularization in acute thrombosis in patients in the acute stage of COVID-19.Materials and methods. The results of open surgical treatment of Rutherford class II acute limb ischemia in patients with acute stage COVID-19 (71 patients, group I) and 50 patients without COVID-19 (group II) were analyzed. The groups are comparable in demographic and clinical characteristics.Results. Hospital mortality was 36,6 % in group I and 10 % in group II. The majority of deaths in group I were due to early retrombosis. Risk factors - coronary heart disease, CKD, diabetes and the emergency nature of surgery had a greater negative impact in group I against the background of coronavirus infection.Conclusion. In patients in the acute stage of COVID-19, endovascular revascularization is associated with a high risk of complications and mortality in the early postoperative period compared with operated patients without coronavirus infection. The influence of all identified risk factors increases against the background of COVID-19, a statistically significant increase in the odds ratio of postoperative complications was revealed for such perioperative risk factors as coronary heart disease, respiratory failure, diabetes mellitus and chronic kidney disease, among the intraoperative factors, the emergency nature of the operation and the duration of surgery are significant.