Effect of pharmacotherapy on the pharmacokinetic parameters of the model substrate antipyrine - a test evidence of the processes of xenobiotic elimination in saliva in patients with mental disorders

Introduction. Medicines (M), including psychotropic drugs, can change the activity of microsomal enzymes of the cytochrome P450-dependent microsomal oxidation system (MOS) of xenobiotics in a patient and lead to a change in the drug level due to drug interference associated with the induction of key MOS enzymes, and to a decrease in the effectiveness of the therapy. The action of psychotropic drugs can largely depend on the rate of their elimination from the body.