Effect of chitosan, photomodulation and physical exercises on the regeneration of operating wounds in experiment

The study was carried out on 60 white Wistar rats, simulating a surgical wound. The rats were divided into 5 groups of 10 rats each. Group 1 - control, rats from this group made an incision on the side wall, abdominal wall, followed by natural healing within 10 days; Group 2 - an incision followed by the use of chitosan ointment; Group 3 - the wound was exposed to photostimulation treated with methylene blue; Group 4 - physical activity in the postoperative period on a treadmill for 30 minutes; Group 5 - complex application of chitosan, photostimulation and physical activity. Wound healing was recorded by determining the area, photo-fixation of the wound was performed, and histological examinations of the skin and internal organs were performed. Obtained results: The best wound healing according to planimetry and histological studies was reliably noted in group 5 with the complex treatment of the surgical wound. Conclusions: The rehabilitation complex for large surgical wounds should include previously local effects of physiotherapeutic procedures and physical activity.