Chorionic gonadotropin effects on eosinophil phagocytic activity in women. The role of Ca2+-accepting proteins

The influence of chorionic gonadotropin (CG), basic hormone of pregnancy, on eosinophil phagocyte activity of the women was investigated. The high doze of CG (100 MU/ml) reduced percent of the phagocytes and uptaken activity of eosinophils, received from the women in follicular phase of menstrual cycle. The hormone in a doze of 100 MU/ml reduced only uptaken activity of the cells in luteine phase. However, an oppressing effect of CG high dose was cancelled at blockade of Ca2 +-accepting proteins by cyclosporine A, irrespectively of phase of menstrual cycle. At the same time, the low doze of CG (10 MU/MI) in a combination with cyclosporine A rendered suppressive effect on phagocytosis, and it was more expressed in a folliculare phase. Thus, CG reduses eosinophil phagocyte activity of the women, but only the high doze of the hormone (100 MU/M1) is effective, and the realization of effects depends on Ca2 +-accepting proteins functioning.