Influence exerted by inhalation burden with formaldehyde on cytokines level in teenagers living in industrial centers

The atmospheric air is polluted with formaldehyde and it exerts negative influence on population health; first of all, the immune system suffers as it is the most sensitive to impacts exerted by environmental factors. Our research goal was to examine levels of specific auto-antibodies and cytokines in teenagers depending on an individual inhalation burden with formaldehyde. We calculated a personified hazard index of inhalation exposure to formaldehyde for each school student. A formula for its calculation included data on air pollution with formaldehyde inside school rooms and teenagers' homes, the atmospheric air pollution, anthropometric and spirometry data, as well as data on school students' daily regime. We examined cytokines and specific auto-antibodies in blood serum of teenagers as these two parameters reflected the immune system state. We revealed correlations between a hazard quotient for exposure to formaldehyde and contents of auto-antibodies to β2-glycoprotein I and to Fc-fragment of IgG, levels of interleukin-2, alpha- and gamma-interferon...