The effect of experimental peritonitis and experimental pneumonia on structural changes in the ovaries of female white rats

At the moment, much attention is paid to the study of new pathogenetic mechanisms of infertility development. Recent studies indicate the influence of extragenital diseases of the respiratory and digestive systems on rats fertility to human women. The aim of this study is to study the effect of experimental peritonitis and experimental pneumonia on structural changes in the ovaries of female white rats. Materials and methods. The study was conducted on 30 white female rats of the Wistar line weighing 300-325 g, divided into 3 groups of 10 individuals each. Peritonitis and pneumonia were modeled by the autocalic method on two different experimental groups, one intact group was used as a control. After modeling the pathology, the right ovary in animals was extracted under anesthesia, subjected to histological treatment, stained with hematoxylin and eosin and analyzed. Morphometric parameters were obtained using light microscopy, and structural changes of the ovaries were evaluated in comparison with the control group. Results. It has been established that experimental peritonitis and experimental pneumonia affect the structure of the ovary, primarily disrupting the normal processes of folliculogenesis, which is reflected in a decrease in the number of maturing and an increase in the number of atritic follicles and bodies. Conclusion. The results of this study confirm the importance of considering the impact of systemic inflammatory diseases, such as peritonitis and pneumonia, on the organs of the reproductive system. The data obtained can be useful for the development of new strategies for the treatment and prevention of infertility.