Endobronchial therapy effect on status localis evolution in case of tracheobronchial tree aspiration injury

Aspiration injury of tracheobronchial system is accompanied by hyper-production of expectorate and bronchial obstruction. This is one of the reasons of the lungs’ hypoventilation progression and pneumonia. The objective of the study is to assess efficiency of endobronchial therapy in aspiration injury of tracheobronchial tree. Treatment results of 407 patients suffering from concomitant trauma complicated by bronchopulmonary aspiration serve as research materials. Among studied patienst were 355 men and 52 women; the age ranged from 16 to 76, APACHE II - 16,47 ± 0,14 points, ISS - 23,46 ± 0,21 points. Unilateral, bilateral diffuse or focal diffuse catarrhal (n = 127), hemorrhagic (n = 162), erosive (n = 46) and croupous (n =72) types of endobronchitis were revealed endoscopically. In treatment of 417 patients, intensive background therapy was combined with daily double inhalations. Treatment of 90 patients included fiber-optic endobronhial instillations of perflourane (daily dose is 0,25 ml/kg). Dynamics of endoscopic semiotics, perflourane effect on mucosa, and cytogram changes of damaged bronchial surface of epithelium was studied. Positive dynamics provided by inhalation therapy was observed in 56,15 % patients, and in 80 % (p